THE TRANSITION FROM PROLIFERATION TO DIFFERENTIATION IN COLORECTAL CANCER IS REGULATED BY THE CALCIUM ACTIVATED CHLORIDE CHANNEL A1.

The transition from proliferation to differentiation in colorectal cancer is regulated by the calcium activated chloride channel A1.

Breaking the balance between proliferation and differentiation in animal cells can lead to cancer, but the mechanisms maintaining this balance remain largely undefined.The calcium activated chloride channel A1 (CLCA1) is a member of the calcium sensitive chloride conductance family of proteins and is expressed mainly in the colon, small intestine a

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The bovine foot skin microbiota is associated with host genotype and the development of infectious digital dermatitis lesions

Abstract Background Bovine Digital Dermatitis (BDD) is a prevalent infectious disease, causing painful foot skin lesions and lameness in cattle.We describe herein the bovine foot skin microbiota and its associations with BDD using 16S rRNA gene amplicon and shotgun metagenomic sequencing on samples from 259 dairy cows from three UK dairy farms.Resu

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POINT CLOUD ORIENTED SHOULDER LINE EXTRACTION IN LOESS HILLY AREA

Shoulder line is the significant line in hilly area of Loess Plateau in China, dividing the surface into positive and negative terrain (P-N terrains).Due to the point cloud vegetation removal methods of P-N terrains are different, there is an imperative need for shoulder line extraction.In this paper, we proposed an automatic shoulder line extracti

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Climate-proofing a malaria eradication strategy

Abstract Two recent initiatives, the World Health Organization (WHO) Strategic Advisory Group on Malaria Eradication and the Lancet Commission on Malaria Eradication, have assessed the feasibility of achieving global malaria eradication and proposed strategies to achieve it.Both reports rely on a climate-driven model of malaria transmission to conc

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